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In three double-blind, placebo-controlled trials in the treatment of influenza in patients at least 65 years old, that enrolled 741 subjects (374 received placebo and 362 received TAMIFLU), no overall differences in safety or effectiveness were observed between these subjects and younger subjects, and other reported clinical experience has not identified differences in responses between the elderly and younger subjects [see Clinical Studies (14.1)]

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Furthermore, a variety of herbal products belonging to the traditional systems of medicine are either already being used by patients with autoimmune diseases, including RA, with or without the primary physicians knowledge, or are under investigation for their therapeutic potential (Venkatesha et al

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