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demonstrated that the GLP-1 analogue lixisenatide decreases atherosclerosis in insulin-resistant Apoe/Irs2+/ mice by promoting macrophage polarization towards an anti-inflammatory M2 phenotype, which was associated with enhanced plaque stability (i.e., thicker fibrous caps, fewer necrotic cores, and decreased inflammatory infiltrates)

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Proteins samples were derivatized with 10 mM of DNPH (final concentration) at RT for 30 min with shaking (500 rpm)

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In addition to gastrointestinal issues, this peptide combination may improve inflammation and wound healing