Mechanism of Action IGF-1 LR3 and IGF-1 both bind to IGF-1 receptors, the stimulation of which activates pathways, including PI3K/AKT and MAPK, to bring about the following effects: Promotion of glucose uptake and subsequent utilisation Increase in energy production in cells Enhancement of glycolysis Increased protein and lipid synthesis Coordination of nutrient uptake Increase in cell proliferation and differentiation Changes in gene expression that support cell cycle progression and tissue growth
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It also regulates gene activity
Sep 2016;67(6):606-13
Previous research has established that VDR is expressed in endothelial cells, vascular smooth muscle cells, and macrophages within the vascular wall being involved in involved in vascular homeostasis [13, 47]
