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GLP-1 medications mimic a natural hormone that helps regulate appetite, slow digestion, and improve satiety

As such the overall impact of the manuscript would benefit greatly by detailed editing and potential re-organization. Response: As per your suggestion, we have replaced the section on requirements and detection of dimers with a reference to the original IUPHAR publication

6 Conclusions and future directions Diet has a major impact on obesity and the composition of the gut microbiota, and in turn, the types of microbial metabolites in the gut

Introduction Although nitric oxide (NO) has been posited as a deleterious molecule from a physiological perspective (Bryan, 2006), it is also known for its crucial role in maintaining the vascular tone

Managing the Transition: Medical Supervision and Lifestyle Strategies If discontinuation is unavoidable, medical supervision during the transition reduces symptom severity and supports metabolic adjustment