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There are natural ebbs and flows in receptor stimulation that support ongoing sensitivity

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The combination of all three (triple agonism) is the design hypothesis: act on appetite, insulin, and energy burn together, with the molecule tuned to be roughly nine times more active at the GIP receptor than the body's own GIP hormone, and somewhat less strongly active at the other two [2]

Amycretin, a novel, unimolecular GLP-1 and amylin receptor agonist administered subcutaneously: results from a phase 1b/2a randomised controlled study