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Overall, weekly injections of semaglutide was linked to reducing the risk of adverse cardiovascular eventsdefined as a heart attack, stroke or deathby 23% compared to dulaglutide

While the potential benefits of BBB opening by itself are still not clear, the proof of safety in transiently opening the BBB of AD patients could additionally allow the delivery of larger molecules such as antibodies or growth factors (Lipsman et al., 2018) that directly target the AD pathology taking advantage of the increased permeability

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Therefore, it is recommended that natural agents should be used as adjunctive therapy for prevention and alleviating migraine attacks