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This is a non-trivial part of the MOTS-c vs Tesofensine comparison, as improper handling can compromise the integrity of an entire experiment

a Refer to Appendix 3 for a graphical representation of the closed testing procedure used in PIONEER 1 to 4 and 8 (Figure 15, Figure 16, Figure 17, Figure 18, and Figure 19)

doi: 10.1016/j.ijbiomac.2025

Sulfur-containing foods include: Cruciferous vegetables like broccoli, cauliflower, cabbage, Brussels sprouts, and bok choy Asparagus Garlic Onion Eggs Glutathione levels can also be increased in the body by consuming foods that are rich in the amino acids cysteine and methionine

Outcome measures Were outcomes measured objectively with body composition scans or only self-reported weight