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they were simultaneously published in the New England Journal of Medicine

10.1039/b910235c J

Ferroptosis is a new form of programmed cell death that plays an essential role in the development of cardiovascular disease

It was originally developed as a type 2 diabetes treatment

Moreover, glutathione has been linked to other health benefits, such as supporting the immune system, improving liver function, and reducing inflammation

In a murine model of renal cell carcinoma, upregulation of G6PD and subsequent increase in NADPH was found to inhibit ferroptosis whereas G6PD knockdown in human hepatocellular carcinoma cells increased positive regulators of ferroptosis 83,84,85