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Several sex effects were also observed throughout these studies, where despite higher levels of total plasma acylcarnitines in females compared to males, in aging females, there was a significant decrease in total acylcarnitines which was not seen in aging males, indicating that aging may impact female peripheral lipid bioenergetics more than males

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The distal enhancer is composed of three functional CANNTG or E-box motifs that bind helix-loop-helix (HLH) transcription factors (42)

HR proficiency was determined by counting the fraction of GFP-positive cells using a BD LSR II at 56 h post I-SceI transfection

And while they are indicative of short-term improvements in glycemic control and/or weight loss, they have less utility for predicting long-term clinical outcomes