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For many participants, symptoms improved or resolved once a stable dose was reached

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To compensate, retatrutide establishes GCGR-specific interactions including stacking with F33 ECD (via F22 P ) and Y138 1.36b (via F6 P ), and three hydrogen bonds with Q142 1.40b (via Y10 P ), Q293 ECL2 (via D15 P ) and Q374 ECL3 (via D9 P )