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Collectively, these clinical data from metformin application in patients with type 2 diabetes suggest that metformin may exert potential modest therapeutic and preventive effects against OA pathology in humans

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Consistent with our findings, L-theanine treatment was shown to restore GSH levels by increasing the activity of antioxidant enzymes in hepatocytes and attenuating ethanol-induced hepatotoxicity in mice [37]

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10.1146/annurev-biochem-061516-045037 148 TakanoT

Consequently, oxygen preferentially accepts one electron at a time