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Studies revealed that in aged rhesus monkeys (20-26 years), Epithalon increased melatonin levels more than 3-fold compared to baseline, restoring circadian patterns characteristic of younger animals

Xing D, Feng W, Nt LG, Miller AP, Zhang Y, Chen Y-F, et al

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Though the pilot study failed to detect the use of TRX-1 as a biomarker of BPD or ROP, this was the first attempt to do so