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T2DM and T2DM-CKD patients exhibit increased gut microbiota TMA-producing bacteria and significantly higher serum TMAO, positively correlating with zonulin, LPS, inflammation, and endothelial dysfunction biomarkers (148)

Adems de estos efectos metablicos, la semaglutida acta directamente sobre los centros de apetito en el cerebro, especficamente en el hipotlamo, reduciendo el hambre y la ingesta calrica

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93 Akt activation increases Mash1 protein levels and transactivation activity are increased during Akt activation, which may indicate a role for the GLP-1-induced PI3K-AKT pathway 96 (Figure 1)

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