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Srgn promotes colorectal cancer metastasis as a critical downstream target of Hif-1alpha

The 'LR3' designation refers to a 13-amino-acid N-terminal extension and a glutamic acid substitution at position 3, which together reduce binding affinity for IGF-binding proteins (IGFBPs) by approximately 100-fold

Ruas JS, Siqueira-Santos ES, Amigo I, Rodrigues-Silva E, Kowaltowski AJ, Castilho RF

The clinical trials showed steady weight loss progression through 68 weeks, with the most rapid loss occurring between weeks 8 and 32

Bartolomucci, A

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