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Insulin signaling also involves feedback through G-interacting vesicle-associated protein (GIV), which enhances phosphoinositide-3-kinase (PI3K)-AKT signaling, and inhibition of phosphatase by NAD(P)H oxidase 4 (NOX4)-derived H 2 O 2

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Low expression of -arrestin 1, but not -arrestin 2, in GH- and PRL-secreting pituitary tumors correlates with a reduced recycling rate of SSTR2 and better SS analogs response in terms of GH suppression, both in vitro and in vivo (67)

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