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Nausea, bloating, feelings of fullness and changes in bowel habits are among the most commonly reported side effects

This early appetite suppression occurs because GLP-1 receptors in the hypothalamus are activated, reducing hunger signals and increasing feelings of fullness

Blood Pressure, 6(1), 24-28

Both Retatrutide and AOD-9604 are available as research peptides in Canada

Pregnancy and severe renal impairment have also been standard exclusion criteria across major trials

This dual mechanism delivers enhanced appetite suppression, improved insulin sensitivity, and greater fat metabolism compared to single-pathway therapies