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This method can allow for higher absorption rates compared to oral supplements

Safe Laxative Options for Semaglutide and Tirzepatide Users Osmotic laxatives like polyethylene glycol (MiraLAX) and magnesium citrate are generally considered first-line choices for GLP-1 users because they work locally in your colon without systemic absorption

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It interacts with your brain chemistry too

A pilot open-label study by Sechi et al

However, careful consideration of timing and skin sensitivity is crucial