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[Google Scholar] [20].Yang X-D, Yang -Y-Y

Mutations in the relevant sites of MTHFR gene can result in a decrease in the enzyme activity of the MTHFR protein, leading to a deficiency of methylenetetrahydrofolate, which can eventually lead to a decrease in the degree of DNA methylation and microsatellite instability, and ultimately can induce colorectal neoplasm [2, 3, 17]

Two patterns appear in the literature

Wang DQ, Lammert F, Cohen DE, Paigen B, Carey MC (1999) Cholic acid aids absorption, biliary secretion, and phase transitions of cholesterol in murine cholelithogenesis

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