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GLP-1 and GIP are colocalized in a subset of endocrine cells in the small intestine

Gut microbiome composition is an emerging factor in medication response

People with Type 2 diabetes have a higher risk of heart attacks and strokes GLP-1s may help reduce these risks

You can't take mother nature's design of a handful of minutes of GLP1 stimulation per day and push it to near constant stimulation every minute of the day and not have consequences

Future research should aim to harmonize differentiation protocols, stem cell sources, and treatment concentrations to better define the therapeutic window and mechanisms of GLP-1-RA in regenerative applications

10.1111/1755-5922.12317 15 GargV.VermaS.ConnellyK