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Site rotation importance Repeatedly injecting in the same location can cause local tissue changes including lipohypertrophy (abnormal fat accumulation) or lipoatrophy (fat loss creating depressions)

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J Biol Chem 284: 768796

At a certain point, they shorten so much that they are no longer able to protect the chromosome and the cell containing the chromosome dies

One medication may be a better fit than the other depending on your appetite patterns, blood sugar concerns, side effects, medical history and how your body responds over time