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If vomiting or diarrhea persists beyond 24 hours or if unable to keep fluids down for 4-6 hours, medical evaluation is warranted to assess for dehydration and potential need for temporary medication adjustment or intravenous fluid replacement

Because retatrutide is not yet approved, post-marketing surveillance data are not yet available

They show how much muscle versus fat is lost and where fat is lost from

[7] The REMS consists of a number of steps that Eli Lilly will take to make physicians aware of the risk of pancreatitis and the potential risk of medullary thyroid carcinoma associated with the drug

Once weekly exenatide: efficacy, tolerability and place in therapy

Exendin-4 induced retching-like behavior mediated by postsynaptic effect via AMPA receptors in the area postrema of mice