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399 In contrast, homeostatic Schwann cell-derived EVs increase DRG neurite outgrowth in vitro and restore small and large fiber functions upon injection into db/db mice

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The main goal of 3D cultures is to provide cells with a bulk ECM with properties that guide cells to develop or sustain a desired phenotype and, implicitly, to rely upon the cells themselves to create a local 3D microenvironment that mimics the in vivo microenvironment