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Crucially, the obesity paradox is likely heavily confounded by two factors: (1) whether weight loss is intentional, and (2) the use of the BMI metric, which poorly reflects the contribution of body composition towards body weight in older adults [15, 34]

The evidence is earlier-stage than it is for skin, but interest is real

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MT-2 exhibits minimal to moderate side effects, low oral and excellent subcutaneous bioavailability in mice

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Studies with the characteristics below were excluded: (1) Animal or cell studies, case reports, experiment protocols, letters, editorials, reviews, or conference papers