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Step 3: Be Consistent

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2024 Dec;20(12):8661-8672

It has been reported that bromelain-induced cytotoxic activity in human gastrointestinal cancer cells (76, 96), breast cancer cells (76, 80), and hepatocellular carcinoma cell lines (97)

A few of these proteins, such as HMGB1, MIF, ANXA1, and LGALS3 are secreted via unconventional pathways [88,89,90], which may explain why their secretion remains unaffected by ER stress