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For those that experience sleep disorders or consistent nights of poor sleep, overall health and cognitive ability are greatly affected - and, ultimately, quality of life
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This signaling cascade, initiated by MDA5 and other sensors during viral infections, culminates in the activation of the JAK-STAT pathway, which is critically dependent on the non-receptor tyrosine kinase 2 (TYK2)
This causes cellular damage and increases oxidative reactions
[2] The idea is that vitamin B12 deficiency can lead to increased homocysteine levels, which would then cause oxidative stress, inflammation, and then joint pain