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Deficiencies of glucagon, epinephrine, cortisol, and growth hormone, which are rare, are usually corrected by exogenous hormone supplementation

however, some patients may experience mild side effects, such as increased hunger or thirst, dry mouth, slight itching at the injection site, and drowsiness

A 2025 European Journal of Clinical Nutrition commentary on the NICE guideline argued that the diagnostic threshold and clinical awareness still need to be tightened further, especially around pernicious anaemia, which is still under-recognised in primary care

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Its very much like were building the plane while flying it. In fact, some of those newer benefits werent even included in their models because the data came out after their analysis was complete

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