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I voted no primarily for low-quality evidence around efficacy, the poor characterization of the bulk drug substance and the fact that there are approved medical therapies for all the proposed uses, Todd Durham, a senior vice president at Foundation Fighting Blindness, said in Fridays meeting

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[30] The discovery of GLP-1's extremely short half-life meant that it was impossible to develop into a drug

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The pelvic floor muscles support the urinary sphincter, so as the muscles grow weaker, the urethra loses its ability to hold in urine