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What factors should providers consider when prescribing GLP-1 agonists to patients, and how can their medical history, such as pregnancy or concurrent medications, influence the treatment plan

STEP 1 Trial (2021) The landmark trial enrolled 1,961 adults with obesity or overweight (without diabetes) and randomised them to semaglutide 2.4 mg weekly or placebo for 68 weeks, alongside lifestyle intervention

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10 Things You Need for Sustained Weight Loss Motivation- find your why Goal setting with realistic timeline Develop a healthy relationship with food and drink Frequent exercise and muscle building Ongoing accountability with a trusted friend or personal journal Self-compassion and creativity to overcome challenges Maintain resilience and perspective to endure setbacks Focus on day-to-day successes Flexible learn from mistakes growth mindset to fine tune healthy lifestyle plan for continued results Enjoy the journey, weight loss is better when youre intentionally thankful, and not frustrated

Ethics declarations Conflict of Interest Andreea Ciudin: Honoraria from AstraZeneca, Boehringer Ingelheim, Lilly, Novo Nordisk

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