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Unlike the pharmacological agents discussed, it is not likely that these dialysis treatment modifications would be undertaken for the primary purpose of enhancing ESA responsiveness, and they therefore were not considered by the Anemia Work Group for inclusion in Guidelines or CPRs addressing ESA adjuvants

Furthermore, a decline in glutathione levels can trigger apoptosis signaling, and supplementation with GSH can inhibit this process, exerting a cytoprotective effect

Many patients see almost no change at this stage, which is expected