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Oral supplementation, while potentially less bioavailable, presents a safer profile with reduced risk of severe reactions and complications

J Toxicol Clin Toxicol 40(6):789801 ten Berg K, van Oppen ACC, Nikkels PGJ, Gittenberger-de Groot AC, Vander Voet GB, Brilstra EH, Lindhout D (2005) Complex cardiac defect with hypoplastic right ventricle in a fetus with valproate exposure

The complexes obtained after docking were used as input for further MD simulations to increase the accuracy of the resulting interactions

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As an example, mercury, lead, cadmium and manganese all damage the central nervous system but with consequences of very different nature