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Beyond protecting against enzymatic cleavage, these alterations also improve the aptamers thermodynamic stability, helping it retain its functional conformation and enhancing its binding performance

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sleep onset insomnia, sleep maintenance insomnia, sleep phase disorders, shift work disorders or jet lag - while overall the evidence is not conclusive, all these conditions require dosing and timing considerations that are slightly different

Endocr Rev 16 : 143163 Mayo LD, Donner DB (2001) A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

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