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Jablonski et al

Because tirzepatide activates both receptor pathways simultaneously, researchers can use it to explore how coordinated incretin signaling influences intracellular signaling networks, hormone-mediated communication between tissues, and metabolic regulation in controlled experimental systems

These insights suggest that colorectal cancer prevention may be most effective when it targets upstream metabolic drivers rather than downstream inflammatory consequences alone

Since that time, the European Medicines Agency (EMA) and the FDA have investigated the issue

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