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The Synergy Hypothesis Bowers et al

Older adults, dehydrated patients, and those taking both GLP-1s and loop or potassium-sparing diuretics warrant heightened monitoring for electrolyte shifts and volume depletion

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Preoperative Assessment Algorithm Systematic preoperative assessment begins with comprehensive medication history, including specific inquiry about weight loss indications that patients may not readily volunteer [53]

The study concluded that glutathione improves aerobic metabolism and significantly decreases fatigue-related psychological factors, offering a clear mechanistic rationale for its use in energy-limiting chronic illnesses