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By comparing the metabolic features of the Pit-1 ^K216E mouse model with other established GHD models, it becomes evident that the metabolic changes observed, such as decreased adiposity, align with those reported in different models of GHD, supporting the attribution of these changes specifically to GHD Moreover, the responsiveness of the Pit-1 ^K216E mouse to GH treatment further validates its utility as a translational tool for understanding metabolic dysregulation in GHD and assessing therapeutic interventions
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You can take them later, outside the 30-60 minute fasting window
