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Understanding the evidence base prevents overestimating results

Sahay S, Khan E, Praveen A, Panthri M, Mirza Z, Gupta M

Amylin Pharmaceuticals

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doi: 10.1212/WNL.0b013e31823ed057 212 van NoortJ

KEAP1-dependent NRF2 activators Electrophilic compounds The most known NRF2 activators are electrophiles electron-deficient species able to form covalent bonds with electron-rich nucleophiles through a variety of chemical pathways which can covalently bind and modify cysteine residues in KEAP1 [273, 274]