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Orforglipron has the potential to redefine the maintenance phase of obesity care, says Fatima Cody Stanford, MD, MPH, an obesity medicine physician-scientist and an associate professor of medicine and pediatrics at Harvard Medical School in Boston, who was not involved in the trial

According to the Mayo Clinic, individuals with diabetic neuropathy experienced physical improvements and reduced pain after monitored use of the amino acid

Studies have shown that a significant proportion of patients experience weight regain after stopping GLP-1 RA therapy, with some regaining up to two-thirds of their lost weight within a year of discontinuation

But as sports physical therapists, we have to look past the bio-hacker headlines and look at the hard data

In contrast with GLP-1, there is a glycine at the second amino acid position in the N-terminus of Ex-4 that can protect the peptide against inactivation and degradation mediated by DPP-4 (130)

Gut 71 , 10201032 (2022)