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Both IGF-1R and IR are preformed dimeric TK receptors made up by two extracellular -subunits and two -subunits involving a small extracellular domain, an intramembraneous one as well as an intracellular domain (Adams et al, 2000)
Ethics statement The requirement of ethical approval was waived by the University of Wisconsin Madison Institutional Review Board for the studies involving humans because this is a retrospective chart review project
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