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Leptin sensitizes NTS neurons to vagal input by increasing postsynaptic NMDA receptor currents

In conditions of nutritional deficit (e.g., fasting or starvation), circulating ghrelin levels rise while LEAP2 concentrations fall, resulting in an increased ghrelin/LEAP2 ratio that enhances GHSR activation [8, 27]

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Spironolactone may also be used for acne vulgaris, polycystic ovary syndrome, and female hirsutism

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