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Critically, GHK-Cu delivers copper as cofactor for lysyl oxidase and lysyl hydroxylase, copper-dependent enzymes essential for collagen cross-linking and stability

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Clinical trials have largely excluded patients with significant gastrointestinal disorders, resulting in limited evidence for safety in Crohn's disease populations

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A: It is best to separate them

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The cleaner independent support is a 2021 study in APP/PS1 Alzheimer's-model mice (Sun 2021, PMID 34827486), which reported improved Morris water maze performance and increased synaptophysin via PI3K/AKT

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