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Biotin-responsive basal ganglia disease maps to 2q36.3 and is due to mutations in SLC19A3

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This is analogous to how 5-Amino-1MQ works in metabolic research-rather than adding a new signal, it removes a brake on an existing one (NNMT inhibition preserves NAD+

While this is effective, it requires medical supervision and is not as accessible as oral supplements

However, off-label use for non-HIV patients should be supervised by a clinician experienced in peptide therapy and metabolic medicine