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Chest 117 , 63S66S (2000)

KPV Preclinical Only (Rodent Colitis Dominates) KPVs strongest preclinical signal is in rodent colitis models (DSS-induced, TNBS-induced), where KPV reduces inflammation, normalizes epithelial barrier markers, and lowers cytokine load

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More recent controlled trials confirm it improves wrinkles, dermal density, and firmness over 12-24 weeks, with significant improvements in skin texture and firmness (particularly with the higher 0.1% concentration)