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The hormone can also reduce COX-2 synthesis directly by blocking the transcription of the COX-2 activator (p52) by inhibiting the activity of p300 histone acetyltransferase (HAT) [33,48]

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Most studies showed decreased GSH levels in AMD patients compared to people without the disease [47,55,56,57,58,59,60]

Mechanistically, vitamin D exerts anti-inflammatory effects via VDR-mediated suppression of TLR signaling, induction of Treg expansion, and downregulation of proinflammatory cytokines such as TNF- and IL-6

Because it is derived from lauric acid, it may not be fungal acne safe