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Patients with certain GLP1R variants may lose weight faster or require lower doses, while others with specific FTO variants may benefit more from combination therapy like GLP-Squared

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Shungus model which builds on Martin Palls ME/CFS NO/ONOO model goes something like this: An immunological trigger or pathogen triggers the production of pro-inflammatory cytokines and the potent free radical peroxynitrite

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However, research showed that GLP-1 was removed from our bloodstream quickly and had a half-life of two minutes as its degraded by an enzyme called DPP4

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Inflammatory or immune-mediated responses represent another theoretical consideration, though there is limited evidence for this mechanism

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Such mutation induces a hyperactivity of the LRRK2 kinase, known to be highly neurotoxic

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