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But if US pharma giants are focused on building impenetrable thickets around every successful drug class, how can smaller players co-own, license, or even innovate in the periphery without facing immediate litigation

Proc Natl Acad Sci 79(2):345349 Ma Y, Huang Y, Yan L, Gao M, Liu D (2013) Synthetic FXR agonist GW4064 prevents diet-induced hepatic steatosis and insulin resistance

Findings in the lung are model-dependent

Diabetes, Obesity and Metabolism, 22 (6), 891903

Diet does much of this work (see below), and some people also consider a targeted supplement

Increasing the number of intestinal endocrine L-cells According to the impairment of L-cells development in T2DM, a promising strategy for treating T2DM is to increase the number of L-cells in the intestine, thereby increasing the production of GLP-1