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AMPK enhances insulin-stimulated GLUT4 regulation via Lowering membrane cholesterol
Aug 11 2011;10:85
Secondary Outcome: Secondary Outcomes: Changes in waist circumference, body fat, body lean mass, and metabolic risk factors including levels of plasma glucose, insulin sensitivity, serum lipids, and blood pressure Statistical Analysis Full details previously published 2 and can also be found in the STEP group statistical analysis plan at NEJM.org Statistical analysis approach sought strong control for type I error All endpoints addressing intervention efficacy were analyzed using intention-to-treat approach All endpoints addressing intervention safety were analyzed using per-protocol approach Efficacy endpoints analyzed using 2 estimands Treatment Policy Estimand: intention to treat analysis
In addition, Src-dependent Cav-1 phosphorylation is a crucial process mediating caveolae-associated endocytosis and eNOS activation in vascular endothelial cells 24,25
Therapeutic targeting of the receptor tyrosine kinase met
