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There is an urgent need for investment in long Covid clinical trials, and in decentralized clinical trials like this one in particular, says Hannah Davis, cofounder of the Patient-Led Research Collaborative, a long Covid research and advocacy group

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The original illustration, based on current pathogenic views [3], was created using Servier Medical Art ( and licensed under CC BY 4.0 ( The lesson from MASH drug trials is that there seem to be numerous different therapeutic targets

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In late 2025, the US medicines regulator (known as the FDA) approved Wegovy tablets as the first oral GLP-1 for weight loss alone [5]

When the dermis is thicker and better organised, the overlying soft tissues sit more cleanly, giving the impression of improved contour and support