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Metabolic syndrome frequently involves endothelial dysfunction (55)

Agric Biol Chem 50:13611363 Schmidt MG, Konetzka WA (1986) Glutathione overproduction by selenite resistant Escherichia coli

Supplementation with 300-600 mg/day has been shown to increase intracellular glutathione levels by 30-70% in cell culture and animal studies, with more modest increases in human trials (Suh et al., Proc Natl Acad Sci, 2004) [25]

GSH also plays an important role in energy metabolism

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At my clinic, we use glutathione injections in a variety of treatments