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CF epithelial models showed decreased expression of several crucial antioxidant enzymes including TRX-1, PRDX-1 and 6, CAT, and GST-pi (Jeanson et al., 2014)

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By selectively interfering with the FOXO4-p53 interaction, FOXO4-DRI has become a compound of interest in research models focused on senescent cell biology and age-associated cellular processes

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