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N Engl J Med 358: 18051810

A 2025 head-to-head trial found tirzepatide produced significantly greater average weight loss (20.2% vs

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The therapeutic mechanism may be associated with accelerated granulation tissue formation, reepithelialization, dermal remodeling, and collagen deposition through ERK1/2 signaling pathway

Due to concerns regarding potential bone loss accompanying substantial weight reduction, further research is needed to determine the long-term effects of cagrilintide-semaglutide on bone mineral density, bone turnover, and fracture risk

Derewenda et al., 1992