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This improvement might stem from specific sphingomyelin (SM)-derived lipids in MPLs, which also correlated with reduced signs of macrophage infiltration in the WAT, indicating lower inflammation [25]

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Metabolic Regulation of Hepatitis B Immunopathology by Myeloid-Derived Suppressor Cells

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For instance, the pleckstrin homology domain interacting protein (PHIP) protein acts as a transcriptional co-regulator that directly modulates POMC transcription, whereas the SIM1 transcription factor is indispensable for the normal development of the PVN and the proper expression of MC4R [8,13]

(PubMed) Harris WS, Von Schacky C